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Imaging and High Content Assays/Screening (HCA/HCS)
HDB offers compound screening and profiling services to assist our clients for lead identification and optimization. We focus our efforts on lead selection and assessment to gear at providing clients with reliable and accurate information through scientific procedures. Panels of profiling assays including biochemical assays and cell-based functional assays (i.e. in various target classes such as GPCRs, enzymes, ion channels and transporters), in vitro ADMET assays and pathway-based cellular phenotypic assays as well as high-content assays offer an integrated tool for clients to better characterize and
optimize the pharmacology and toxicity profiles of their lead compounds.
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Genotoxicity and cytotoxicity (micronucleus test; tube formation; caspase activation)
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Cell signaling and transcription factors
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Cell proliferation and cell cycles
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Apoptosis and viability
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Kinase translocation and GPCRs redistribution
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Morphological and phenotypic changes
Imaging Platform
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Automated cell imaging systems, ImageXpressMICRO™ (Molecular Devices)
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Powerful analysis software: MetaXpress™ Software and Assay Application Modules
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AcuityXpress™ Cellular Informatics Software
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Advanced large scale data storage and IT support
Service Features:
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Subcellular localization and quantitation of the cellular targets
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Multiplexing capabilities: multiple data points from a single assay well
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Parallel analysis of functional activity and cytotoxicity in one assay well
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High sensitivity (nuclei staining allows for normalization of cellular signals against cell number)
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Measurement of individual cell responses in the heterogeneous cell populations
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Application of drug to live cells may indicate side-effects at the early stages of drug development
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Cell based assays provide a biologically relevant assessment of compound functional activity
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Robust and cost-effective assays
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Minimum compound requirement (96 or 384-well plate format)
Compound Profiling
Pharmacology profiling has become an invaluable tool for leadcompound selection, optimization and candidate prioritization. Analysis ofprofile data identifies off-target interactions that can help predict potential side-effects, efficacy and safety of compounds under development before theyprogress to the more costly stages of preclinical and clinical trials. HDBoffers comprehensive profiling services to fit our clients' drug discovery
&development needs.
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HD Biosciences (China) Co.,Ltd
590 Ruiqing Road
Zhangjiang East Campus, Pudong, Shanghai 201201,
P.R.China
Tel: +86 (21) 5116 3700
Fax: +86 (21) 5116 3766
info@hdbiosciences.com
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